| ncRNA name | MMP-9 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Bos taurus |
| Tissues/Cell_line | bovine retinal endothelial cells (BRECs) |
| Methods | siRNA transfection, TUNEL assay, bicinchoninic acid assay, ELISA, mitochondrial genome-specific quantitative extended-length PCR, Western blot |
| Expression pattern | associated |
| Functional description | Regulation of MMP-9 by siRNA prevented a glucose-induced increase in mitochondrial MMP-9 and cell apoptosis. Furthermore, a decrease in mitochondrial Hsp70 and Hsp60, and increase in the binding of MMP-9 with these chaperone proteins, experienced by BRECs in high-glucose conditions, was also ameliorated in the cells transfected with MMP-9 siRNA. |
| PubMed ID | 21933988 |
| Year | 2011 |
| Title | Abrogation of MMP-9 gene protects against the development of retinopathy in diabetic mice by preventing mitochondrial damage. |
| Drug-related ncRNA | NO |
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